The purpose of the present investigation was to formulate and evaluate the enalapril maleate nail lacquer as preungual drug delivery system for the treatment of hypertension. Enalapril Maleate was chosen as the model drug, and the formulations were prepared with and without polymer Eudargit RL 100 within the concentration range of 1% to 5% (w/v) in the polymeric system. Then, these lacquers were compared for glossiness, film formation, drying rate, smoothness of flow, and nonvolatile content. The in vitro studies were preformed on the artificial membrane in solvent A (phosphate buffer, pH 7.4; and methanol, AR grade, in the ratio of 4:1). The result obtained indicated that the nail lacquer formulation showed good release of the drug. Thus nail lacquers can be used as a successful tool for targeted drug delivery for hypertension.
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